MYC and adenoviridae infectious disease: Although previous studies have reported a critical role for increased glutamine consumption and the anaplerotic use of glutamine in host cells infected by HCMV or VACV7, 15, our results tracing the fate of glutamine carbons during adenovirus infection and using a MYC activation-deficient mutant virus have implicated the MYC-directed use of glutamine in additional metabolic pathways, some of which have not been previously characterized in virus-infected cells and are not canonically known to be regulated by MYC.