GLS and adenoviridae infectious disease: Since MYC enhances glutamine metabolism in cancer cells in part through promoting increased expression of glutaminase (GLS)8 and the glutamine transporters ASCT2 and SN2 (ref. 9), we hypothesized that E4ORF1-induced MYC activation may enhance glutamine metabolism during adenovirus infection through modulation of GLS and glutamine transporter levels.