We detect increased transcript levels of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2), nicotinamide nucleotide transhydrogenase (NNT), pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) and glutamic-oxaloacetic transaminase 2 (GOT2) in host cells at 8 h post infection with AD WT, but not in cells infected with AD ORF1 D68A (Supplementary Fig. 1e). The gene discussed is NNT; the disease is infection.