Moreover, EGF stimulation can enhance nuclear translocation of MDA-9/Syntenin, and the nuclear MDA-9/Syntenin interacts binds with Slug to form the transcriptional repression complex within the nucleus, enhances Slug transcriptional repressor activities, and promotes EMT, invasion, and metastasis in lung adenocarcinoma. Here, SDCBP is linked to lung adenocarcinoma.