As shown in Figure 8, miR-181c levels in 10 freshly collected pancreatic cancer samples were significantly positively correlated with mRNA levels of the Hippo downstream genes CTGF (r = 0.767, P = 0.010) and BIRC5 (r = 0.795, P = 0.006), as well as nuclear expression levels of YAP (r = 0.762, P = 0.010) and TAZ (r = 0.661, P = 0.038). Here, CCN2 is linked to familial pancreatic carcinoma.