CCN2 and neoplasm: In turn, the activated TEADs transcriptionally upregulate multiple downstream effectors to exert a pleiotropic role in tumor progression, including connective tissue growth factor (CTGF), baculoviral IAP repeat containing 5 (BIRC5) and BCL2-like 1 (BCL2L1), leading to the promotion of cell survival and chemoresistance [15, 30–32].