With the treatment of BV (0–5 μg/ml) in HCT116 and in SW480 colon cancer cells, we found that the expression of pro-apoptotic proteins such as Bax, cleaved caspase-3, cleaved caspase-8 and cleaved caspase-9 as well as the expression of DRs like DR3, DR4, DR5 and Fas was increased in a concentration dependent manner. This evidence concerns the gene CASP8 and colonic neoplasm.