CASP3 and neoplasm: The immunohistochemistry analysis of tumor section by hematoxylin and eosin staining and proliferation antibodies against PCNA staining revealed that BV (1 mg/kg) significantly suppressed tumor growth, and the expression level of DR4, DR5 and active caspase-3 was increased while the expression level of p50 was decreased in nude mice xenograft tissues (Figure 9D).