Clustering analyses of immunohistochemistry of HNSCC and normal oral mucosa tissues showed that p-STAT3T705 expression positively correlated with LAMP2 (P = 0.0003, r = 0.4315) and p-Erk1/2T202/204 (P = 0.0055, r = 0.3408) but negatively correlated with the autophagic marker LC3 (P = 0.0340, r = −0.2634) (Figure 6B). This evidence concerns the gene MAPK3 and head and neck squamous cell carcinoma.