The present study investigates subjects with a wide BMI range via quantitative measurement of circulating eCBs and their related compounds as well as genotyping for the 385C>A polymorphism in FAAH. These variables are used to identify the obese phenotype associated with insulin resistance, dysregulation of adipocytokines (leptin and high molecular weight adiponectin) and cardiometabolic biomarkers. Here, LEP is linked to Insulin resistance.