There was a significant increasing trend in AEA (Fig 1A), 2-AG (Fig 1B), WC (P<0.001), insulin (P = 0.005), HOMA-IR (P = 0.004), leptin (P = 0.008), hsCRP (P = 0.002), along the three degrees of obesity. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.