In conclusion, we have found that the alternations in the genotype and allele frequency of IL-1β (−511C/T), TNF-α (−308 G/A), TNF-α (−238 G/A) and IL-10 (−1082 G/A) genes are associated with an higher risk of sepsis development in trauma patients and outcomes. The gene discussed is TNF; the disease is Sepsis.