As for clinical relevance, eight polymorphic loci IL-1α/-889, IL-1β/-511, IL-1R (pstI 1970), TGF-β/ codon 25, TNF-α/-308, TNF-α/-238, IL-6/+565, and IL-10/-1082 have been shown to be significantly associated with sepsis morbidity and outcome that may be used as a determinant of risk factor for the outcome of trauma patients. The gene discussed is TNF; the disease is Sepsis.