MAT1A and hepatocellular carcinoma: These findings are consistent with previous reports that show roles for forced miR-485-3p expression in promoting tumorigenesis and metastasis in mice [69], indirectly affecting sensitivity to etoposide and fludarabine by fine tuning DNA Topoisomerase II expression via nuclear factor-YB [70, 71] and by regulating methionine adenosyltransferase 1A expression in hepatocellular carcinoma [69].