IL-8RBA was involved in the augmentation of tissue injury in SLE during inflammatory responses by cooperating with FcgammaRIIa and enhancing polymorphonuclear leukocyte (PMN) recruitment in the presence of anti-endothelial cell antibodies (AECAs), which were commonly detected in diseases associated with vascular injury, including SLE52. This evidence concerns the gene FCGR2A and systemic lupus erythematosus.