Seven of the 10 common targets (guanine nucleotide binding protein [G protein], alpha inhibiting activity polypeptide 2 [H_LUCA16.1], chemokine ligand 3 [SCYB3], chemokine ligand 1 [SCYB1], guanine nucleotide binding protein alpha 15 [GNA16], chemokine ligand 2 [SCYB2], chemokine ligand 5 [SCYB5], chemokine receptor 1 [IL8RBA], guanine nucleotide binding protein alpha 14 [GNA14], pro-platelet basic protein [THBGB1] and chemokine ligand 5 [SCYB6]) participated in the chemokine signaling pathway that was involved in SLE pathogenesis53. This evidence concerns the gene PPBP and systemic lupus erythematosus.