Interestingly, ISCU expression was significantly higher in hepatocellular carcinoma tissues with wild-type p53 compared to those with mutant p53 (Fig. 5e, 1843.3 ± 618.1 vs 1567.7 ± 647.7, P = 2.9 × 10−4)32, further supporting the in vivo regulation of ISCU by p53. The gene discussed is TP53; the disease is hepatocellular carcinoma.