Inhibition of GSK3β by thiadiazolidinone (TDZD) in MM.1, U266, and other myeloma cells resulted in the inhibition of cell proliferation and induction of apoptosis via the dephosphorylation and activation of FOXO3a as well as increase of FasL and IκBα levels13. This evidence concerns the gene GSK3B and plasma cell myeloma.