Inhibition of GSK3β by thiadiazolidinone (TDZD) in MM.1, U266, and other myeloma cells resulted in the inhibition of cell proliferation and induction of apoptosis via the dephosphorylation and activation of FOXO3a as well as increase of FasL and IκBα levels13. The gene discussed is FOXO3; the disease is plasma cell myeloma.