Treatment with exogenous dNs increased the total infection levels and the percentage of single and double infected cells of the TN phenotype (p = 0.002 and p = 0.03, respectively, Fig. 6a), consistent with our previous finding that SAMHD1 was a more potent restrictor of HIV infection in TN cells than in TCM or TEM cells. This evidence concerns the gene SAMHD1 and infection.