SAMHD1 and HIV infectious disease: This was in part due to SAMHD1-mediated restriction of HIV infection in naïve cells, as knockdown of SAMHD1 via Vpx-containing viral like particles (VLPs) resulted in an ~20-fold increase in EGFP expression in the TN subset compared to only 5–8–fold increases in TCM and TEM subsets [25].