As TCM cells are among the longest-lived subsets of CD4+ T cells and are a primary contributor to the latent reservoir in patients treated with antiretroviral therapy [35], their preferential double infection implies that these cells may represent an archived population of cells with multiple proviruses that can drive ongoing recombination in vivo, with significant implications for the reshuffling of viral genomes during periods of treatment interruption or intermittent viremia. This evidence concerns the gene CD4 and infection.