Even though the differences and the variable expression of driver genes for cancer formation (ErbB2, Akt3, Pik3ca) was documented in cervical, endometrial and vulvar carcinoma, the positive correlation of the differentially expressed genes of the three types of gynecological cancers with modules (Myc), pathways (Wnt, ErbB, Toll-like receptors) and biological processes lead us to assume that there is more than one operating gene network that regulates the same functions and pathways. Here, PIK3CA is linked to cancer.