E2f transcription factor family is associated with cell cycle regulation targeting cyclin A2 (Ccna2, upregulated in cervical and endometrial carcinoma), cyclin D1 (Ccnd1 upregulated in endometrial carcinoma), cyclin-dependent kinase 2 (Cdk2, upregulated in cervical cancer) and apoptosis-related genes such as Casp3 (upregulated in cervical cancer) and Casp8 (upregulated in endometrial cancer). The gene discussed is CASP3; the disease is endometrial cancer.