Key gene components such as Nras (upregulated in all gynecological cancers), Pik3ca (upregulated in cervical cancer, downregulated in endometrial cancer), and Jun, Akt3 (downregulated in endometrial and vulvar cancer), which are also involved in known cancer- related pathways, showed variable expression in all three gynecological cancers. This evidence concerns the gene AKT3 and vulva cancer.