Key gene components such as Nras (upregulated in all gynecological cancers), Pik3ca (upregulated in cervical cancer, downregulated in endometrial cancer), and Jun, Akt3 (downregulated in endometrial and vulvar cancer), which are also involved in known cancer- related pathways, showed variable expression in all three gynecological cancers. The gene discussed is PIK3CA; the disease is endometrial cancer.