Furthermore, transcription factors Stat1, Stat3, Cebp, E2f1, E2f4, E2f6, Fos, Myc, Ap2 and Jun were all enriched in the upregulated genes, with a relative ratio ranging from 1.5 to 15 (Fig 4D) for upregulated against downregulated genes (S2 Table), when annotated in a region of 5 kb around TSS (-2500 to +2500 bp) of the differentially expressed genes in cervical cancer patients. The gene discussed is E2F4; the disease is cervical cancer.