IL2RA and fibrosis: IL-2R is primarily secreted by activated T-helper lymphocytes and is widely expressed on activated T lymphocytes, regulatory T cells, B cells, and monocytes.32 Some studies have examined IL-2R in chronic liver disease and found increased IL-2R in hepatic cirrhosis.33–36 However, the performance of IL-2R in diagnosing liver inflammation and fibrosis had not been determined.