International recommendations for the assessment of autoantibodies to cellular antigens referred to as antinuclear antibodies15 says: “Theoretically, if ANA-indirect immunofluorescence assay is negative, one should not proceed to defining anti-dsDNA antibodies, although if clinical suspicion of SLE is substantial anti-dsDNA antibodies assessment may be requested by the clinician.” On the basis of these facts, we think that it does not matter to diagnose our case with SLE. This evidence concerns the gene BTG3 and systemic lupus erythematosus.