In our previous study, we performed a genome-wide gene expression analysis to identify differentially expressed genes in ccRCC tumoral tissue compared with adjacent nontumoral renal tissue from the same patient.31 We reported 4 novel RCC associated biomarkers, PTP4A3, LAMA4, KCNJ1, and TCF21 genes, showing high sensitivity. The gene discussed is TCF21; the disease is renal cell carcinoma.