First, the TLR on 4P14, the lead SNP was rs10004195, closely followed by rs4833095 polymorphism has been associated with gastroduodenal disease and GC with susceptibility to H. pylori. At the mechanistic level, this may be explained by the mutation causing reduced ghrelin, IL-10 levels in response to H. pylori, thereby resulting in diminished IFN-γ-mediated TNF-α response. This evidence concerns the gene GHRL and gastric cancer.