In this cross-sectional study of drinking habits and markers of prostate health as well as reproductive hormone profiles in Chinese men, we observed that current drinkers had, on average, lower value of free PSA and f/tPSA ratio, former drinkers also had lower level of free PSA compared with never drinkers, whereas alcohol consumption had no obvious impact on prostate-related symptomatology as measured using the I-PSS. The gene discussed is KLK3; the disease is urogenital neoplasm.