LEPR and obesity due to melanocortin 4 receptor deficiency: Reported LEPR associations with obesity among children and adolescents have also been inconsistent: Mexican (n = 128) and Polish (n = 142) studies found no association between LEPR rs1137100 [K109R] and obesity [16, 34], whereas a small study of 136 Japanese children found the rs1137100 A-allele to associate with increased risk of being overweight [35].