PTEN and cancer: In LN, 44 different genes are observed, out of which 17 cross-talk genes are common in CM too, which includes important genes like NRAS, PTEN and CDK1. The observed 27 new cross-talk genes in this multi-pathway cross-talk event in LN include cancer related genes like AKT1, AKT2, MAPK3, KRAS, JAK1 and JAK2. Investigation of cross-talk potential elucidates 53 different genes with cf > 10, out of which only 19 genes are common with CM.