The gene set is enriched with several melanoma-associated genes including MAGEA1, MAGEA12, IL8, FOXD1, IL1B, POSTN, PRAME, MMP9, SERPINE and CTGF. Genes conserved between metastatic stages (n = 67) too holds several key regulators of melanoma like VEGFA, GDF15, SPP1, UPP1, SPRY4, FGF2, CENPN, SERPINA3, BUB1. The complete list of both gene sets along with its description is given in the S2 File. This evidence concerns the gene SPRY4 and melanoma.