Expectedly most of the pathways that occur in each stage were melanoma or cancer causing and covers wide range of oncogenic events, e.g. immune response, cell cycle, apoptosis, hypoxia related events, signalling pathways in cancer including EGFR signalling, PI3K/Akt signalling, MAPK signalling, WNT signalling and other related pathways. This evidence concerns the gene AKT1 and cancer.