The oncogenic potential of most of these genes is already well recognized (e.g. SRC, NRAS, VEGFA, NFKB2 etc.), this validates our findings and the dataset as well as suggests that the other genes in the list for example MCTS1, ELK1 and ZNF146 may be further investigated for its potential role in melanoma metastasis. Here, NRAS is linked to melanoma.