In these two genetic subgroups, the median OS of patients with IDH wild-type gliomas was also significantly shorter than that of patients with IDH and TP53 mutant gliomas (Table 1B and Fig 1D; hazard ratio = 0.270; 95% CI: 0.155–0.460; p < 0.0001). Here, IDH2 is linked to central nervous system cancer.