However, tumors harboring +8q, −9p, −11p, and +12p were frequently found after subsequent surgeries (Fig 3); +7q, +8q, −9p, −11p, and +12p emerged between the initial surgery and recurrent surgical interventions in 0, 2, 4, 3, and 4 cases of IDH mutant gliomas with TP53 mutations, respectively. Here, IDH1 is linked to central nervous system cancer.