Recently, Lueg et al. also assessed alterations of T cell subsets in the intrathecal compartment of cognitively impaired and cognitively intact elderly subjects as well as healthy younger control individuals and found a significantly increased proportion of CD8+ lymphocytes in the CSF of patients with Alzheimer’s disease – but not in patients suffering from other dementias – which correlated with cognitive deficits [33]. Here, CD8A is linked to early-onset autosomal dominant Alzheimer disease.