TTR and amyloidosis: In a Japanese observational study [34], 22 patients with TTR Val30Met mutation and 3 with Tir114Cis mutation (Tyr114Cys) were observed and it was found that 3 (12%) had glaucoma, 3 (12%) had amyloid deposits on the pupil edge, and 1 (4%) developed vitreous opacities.