Chen et al. took a LPH (liposome-polycation-hyaluronic acid) nanoparticle formulation modified with tumor-targeting single-chain antibody fragment (scFv) for systemic delivery of miR-34a into lung metastasis of murine B16F10 melanoma, prompting significant downregulation of survivin expression in the metastatic tumor and reduced tumor load in the lung [78]. Here, BIRC5 is linked to neoplasm.