To determine if Xiaoqinglong mixture could enhance host immune responses to influenza infection by inducing IFN system, the expression of IFN-α/β and IFN-stimulated genes (ISGs) was determined in RAW264.7 cells infected with A/Fort Monmouth/1/1947 and treated with 40 μL/mL Xiaoqinglong mixture. This evidence concerns the gene IFNA1 and influenza.