In summary, through our research, we initially demonstrated the existence of CASP1-6, CASP1-7, CASP1-alpha, CASP1-beta, and CASP1-gamma transcript variant in PBMCs of gout patients, and the expression of each transcript variant mRNA showed difference between patients with gout in different TCM syndromes and health controls, combined with relevant laboratory index; the results preliminarily indicated that CASP1 gene and its transcript variant might play an important regulating role in the pathogenesis of gout. The gene discussed is CASP1; the disease is gout.