In conclusion, obstruction of dampness and heat syndrome and intermingled phlegm-stasis blood syndrome tend to occur in the acute phase of gout, while Pi-deficiency induced dampness syndrome and Qi-blood deficiency syndrome tend to occur in the nonacute phase of gout, and the mechanism may relate to the dysregulated expression of CASP1 gene and its transcript variant; the expression change of CASP1 gene and its transcript variant may be associated with the onset of gout. The gene discussed is CASP1; the disease is gout.