PON1 and type 1 diabetes mellitus: In the case of HDL2, this may be related, in part, to the increased SAA protein identified in the T1DM subjects, and, in the case of HDL3, this may be related to changes in the concentration of other HDL-associated proteins, such as paraoxonase-1, which readily associates with HDL3 [32] and is influenced by inflammation [33].