Since recent studies pointed out the CSC subpopulation in tumours (including brain tumours) as the leading driver of malignant progression and relapse [31] and previous results reported in this study clearly showed that PI3K/AKT downmodulation led to MDB cell growth inhibition, induction of cell death, and cellular differentiation, we examined the possible relationship between differentiation and cell death in MDB primary cells. Here, ABR is linked to neoplasm.