To evaluate the effects of BKM120 and BEZ235 on PI3K/AKT/mTOR signaling, we analyzed the phosphorylation status of Akt and some downstream targets (including mTOR, 4EBP1, and p70S6kinase) in lymphoma cell lines treated for 24 h with the IC50 of these drugs. The gene discussed is MTOR; the disease is lymphoma.