PLK1 and cancer: TKM-080301, which was developed by Tekmira Pharmaceuticals Corp., is a lipid nanoparticle- (LNP-) based formulation of a (si)RNA that targeting human PLK-1 mRNA and has shown not only potent antiproliferative activity and gene-specific silencing against many human cancer cell lines but also potent antitumor activity against several xenograft models of human cancers.