SBE13 showed a 1000-fold greater inhibition selectivity among PLK family members, and a wide range of cancer cell lines have been screened to evaluate the anti-proliferative effect of SBE13, and it caused G2/M arrest at higher concentrations (http://www.tandfonline.com/doi/pdf/10.4161/cc.9.3.10721). The gene discussed is PLK1; the disease is cancer.