JAK2 and colonic neoplasm: Among these bioactive compounds presented in TCEE, 4,7-dimethoxy-5-methy-1,3-benzodioxole is suggested to suppress colon cancer cells via the activation of P53-dependent P27 pathway without induction of P21 [27], sesquiterpene lactone antrocin activates caspase-3 associated apoptosis on lung cancer cells via suppression of JAK2/STAT3 pathway [32], and also various triterpenoids activate poly(ADP-ribose) polymerase (PARP) associated cell death on prostate cancer cells [33].