(5) Pre-clinical testing and validation of appropriately chosen targets [e.g., JMJD3, H3K27 demethylase (137), Menin (138), ACVR1 (24)] in available tumor models (138, 139) will help to identify novel effective therapies and provide options to personalize treatment and limit side effects and long-term toxicities. This evidence concerns the gene ACVR1 and neoplasm.