TGFB1 and liver dysplastic nodule: Pathway enrichment analysis with the central nodes had an acceptable validity as most of the enriched pathways including TGFB, VEGF, MAPK, and BMP signaling pathways were previously shown to be associated to DN in experimental studies (Toyoda et al., 2004; Turk et al., 2009; Ziyadeh, 2008).