IL5 and Increased total eosinophil count: The pivotal role of adipose tissue resident immune cells (i.e. macrophages and mast cells as well as proinflammatory adipocytokines) makes them targets for novel biological treatments such as peroxisome proliferator activated receptor (PPAR) agonists and, in particular, in association with sputum eosinophilia, anti-interleukin (IL)-5 (16, 17).