APOA1 and serum lipopolysaccharide activity: Made from purified human ApoA1 and soybean phosphatidylcholine (PC) at a molar ratio of 1:2 protein to lipid, CSL-111 has repeatedly shown efficacy in reducing the burden of LPS-induced endotoxemia both in vitro and in vivo in rabbit and human models (Casas et al., 1995; Hubsch et al., 1995; Pajkrt et al., 1996).