(1 a) Prophylactic rHDL: reduced plasma LPS and TNF-α; reduction in metabolic acidosis; no effect on hypotension or blood bacterial levels(1 b) rHDL Treatment: reduction in LPS after 4 h; reduced metabolic acidosis and creatinine; no effect on blood bacterial counts or TNF-α; no effect on hypotension(2) No effect in Gram (+) sepsis. This evidence concerns the gene TNF and Sepsis.