Moreover, given that hippocampal calcium homeostasis is known to be disrupted in acquired forms of epilepsy (Delorenzo et al., 2005), and intracellular calcium signaling is critical to the maintenance of neuronal function (Mattson et al., 2000), one likely outcome of CB loss in Bsn-mutant dentate granule cells is an overall negative effect on neuronal viability and synaptic plasticity. This evidence concerns the gene BSN and epilepsy.