In contrast, in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD), subsets of TDP-43 containing cytoplasmic inclusions label for SG markers such as TIA-1, eIF3 and PABP (Polyadenylate-binding protein; Volkening et al., 2009; Dormann et al., 2010; Liu-Yesucevitz et al., 2010; Bentmann et al., 2012; McGurk et al., 2014), (Table 1). The gene discussed is EIF3A; the disease is amyotrophic lateral sclerosis.