SOD1 and amyotrophic lateral sclerosis: For instance, in hypoxia-reoxygenation injury (Ding et al., 2010) and in neurodegenerative diseases such as Parkinson’s disease (Barcia et al., 2012), ROCK inhibition resulted in a reduction of microglia while in a SOD mouse model of amyotrophic lateral sclerosis (ALS) the ROCK inhibitor Fasudil induced an increase in microglia density and a reduction of reactive astrogliosis (Tönges et al., 2014).