The RhoA pathway and its downstream effector ROCK are activated under various pathological conditions including Alzheimer’s (Zhou et al., 2003) and Parkinson’s diseases (Rodriguez-Perez et al., 2013), spinal cord injury (Fournier et al., 2003), global cerebral ischemia (Castro-Alvarez et al., 2011), traumatic brain injury (Dubreuil et al., 2006) as well as in epilepsy (Dubreuil et al., 2006; İnan and Büyükafşar, 2008; Jeon et al., 2013). The gene discussed is RHOA; the disease is epilepsy.