In addition, although the role of type I IFNs and certain RLRs, such as RIG-I, have been recently confirmed in classic DM as found to be expressed at higher levels in muscle biopsies and human myotube cultures [21], clinical results from sifalimumab (anti-IFN-alfa mAb) need to be confirmed in larger trials as well as circulating IFN-alfa as a potential biomarker in MDA5-positive dermatomyositis need to be assessed by adequate protocols [22]. This evidence concerns the gene RIGI and dermatomyositis.