PTPN11 and Noonan syndrome: Src homology-2 (SH2) domain-containing phosphatase 2 (SHP2, also called PTP11, PTP-1D, or PTP-2C) is a ubiquitously expressed phosphatase that is associated with multiple neoplastic malignancies, as well as three closely related inherited developmental disorders [180–182], the Noonan syndrome, the Noonan-like disorder with multiple giant cell lesion syndrome, and the LEOPARD syndrome, that include, among many other defects, lymphatic malformations and bleeding difficulties [183].