Across a diverse range of epithelial-derived cancer cell types, high miR-200c expression can enforce an epithelial state by repressing the expression of E-cadherin transcriptional repressors ZEB1 and ZEB2, whereas inhibited expression of miR-200c in mesenchymal cancer cells leads to upregulation of ZEBs and induces downregulation of E-cadherin. This evidence concerns the gene CDH1 and cancer.