Two cell lines formed tumor in all mice, in the comparison in three groups of each cell lines, we found the same results that lymph nodes of metastasized tumor cells from the mice in TCP-1 shRNA a group were smaller and lighter than those in the control shRNA and control group, no difference was found between control shRNA group and control group (Figure 6B and 6C). The gene discussed is TCP1; the disease is neoplasm.