Serum amyloid A (SAA) purified from the plasma of patients with RA, or recombinant SAA, suppressed both spontaneous and α-FAS (CD95) induced-neutrophil apoptosis of human neutrophils in vitro; Oxidized ATP is an unselective P2X7R antagonist and it can attenuate inflammatory responses independent of P2 receptor blockade and inhibit this SAA-mediated anti-apoptotic effect [30]. This evidence concerns the gene FAS and rheumatoid arthritis.