Besides, caspase as an important apoptosis pathway is closely related with P2X7R. Studies have found in skin neoplasias of mice the activation of P2X7R can activate caspase-9 and caspase-3 so as to activate the mitochondrial - caspase-9 apoptosis pathway [40]; the study of TCP-1 also found that in uterine cancer cells the disruption of TCP-1 activates both intrinsic (caspase-3, caspase-6, caspase-7, and caspase-9) and extrinsic (caspase-2,caspase-8, and caspase-10) caspase-dependent apoptotic pathway [41]. This evidence concerns the gene CASP8 and uterine cancer.