The previous reported results suggest that CCL2 is a key player for tumor progression [43–45], and urinary CCL3 levels could be linked to the tumor stage, grade and distant metastasis [46–48], and patients with stages T2–T4 BCa have a three- to four-fold higher mean CCL2 concentration in their urine than those with T1 stage tumors [47]. Here, CCL2 is linked to neoplasm.