Treating the other lung adenocarcinoma cell lines with 250 pM of either TIMP-2 or TIMP-2 C72S stimulated 1.4-fold to 1.7-fold increases in cell proliferation in a statistically significant fashion (p < 0.05) when compared with untreated cells (Figure 1C–1E). This evidence concerns the gene TIMP2 and lung adenocarcinoma.