Accordingly, it was recently discovered that overexpression of the CRNDE gene may suppress apoptosis and promote growth and invasion of gliomas both in vitro and in vivo either in a manner depending on the mammalian Target of Rapamycin (mTOR) pathway [6] or by inhibiting the expression of the tumor-suppressing miR-186 [7]. The gene discussed is MTOR; the disease is central nervous system cancer.