ATRX and central nervous system cancer: As expected, we found highly frequent ATRX inactivation (∼92.9%) in TERT wild-type gliomas in the present study (Figure 2), and demonstrated that the RTL was significantly longer in ATRX-negative tumors than that in ATRX-positive tumors (Median, 0.90 vs. 0.49; P = 0.002) (Supplementary Figure S2C).