Sirtuin-1 (SIRT1), a NAD+ dependent class III histone deacetylase, has a number of cellular substrates including PGC-1α, NCoR, p300, NFκB, FOXO and p53 and has been implicated in regulation of metabolism, chronic inflammatory diseases, cancer and aging A direct role of SIRT1 in promoting keratinocyte differentiation has been shown and is supportive of earlier findings that resveratrol, a plant derived polyphenol which activates SIRT1, inhibited proliferation of human keratinocytes and suppressed angiogenesis in vitro. Here, SIRT1 is linked to cancer.