S100A12 and psoriasis: As shown in Fig 3, other genes that were strongly suppressed by SRT2104 included the serine protease inhibitors (SERPINB4, SERPINB3, SERPINB13), members of the S100 family of proteins (S100A7, S100A12), SPRR2c, etc. previously shown to be highly upregulated in psoriasis [13].