To this end, a selective antagonist of ER-β, 4-[2-Phenyl-5,7-bis(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-3-yl] phenol (PHTPP) had been shown to decrease the mucus plugging in chronic inflammatory conditions of the airway and reduce bladder cancer cell growth and invasion [34,35]. Here, ESR2 is linked to urinary bladder carcinoma.