TRPC4AP and Behcet disease: The miRNA miR-499 is located in a region on chromosome 20q11 that showed genome-wide significant association in a previous GWAS of BD.45 As miR-499 is located in a region of high LD, which includes the genes GSS, MYH7B and TRPC4AP (Figure 2), further analyses of this chromosomal region are required to refine the association signal.45 However, miR-499 represents a very promising candidate in this region.