These include CREB1 that has previously been identified as a susceptibility gene for major depressive disorder.61, 62, 63 In addition, CREB1 was found to be associated with BD in a recent study of large-scale BD samples64 that included 8403 patients and 11 588 controls of our BD GWAS.6 However, the present pathway analysis provided no strong evidence for an enrichment of biological processes of relevance to psychiatric disorder. The gene discussed is CREB1; the disease is major depressive disorder.