This finding is supported by a large and comprehensive genetic study for depression including more than 18 000 individuals in the discovery phase and more than 57 000 individuals in the replication phase, found no evidence of association between depression and the chromosome region comprising SORT1. 42 Interestingly, however, the intronic SNP, rs11581665, was significantly associated with serum sortilin levels. Here, SORT1 is linked to major depressive disorder.